Most travelers arrive in Santorini by boat. Ferries depart several times a day from the port at Piraeus, near Athens, and the voyage takes nine to ten hours by car ferry or four hours by catamaran. Upon arrival in the port of Athinios, shuttles are available for the transfer to Fira. Those arriving by yacht or small ship will dock at the Old Port and can take a cable car or ride a donkey up the cliff to Fira. The lodge is a two-kilometer drive from Fira by taxi or rental car, and transfers can be arranged by the hotel.

Several Greek airlines fly from Athens to Monolithos, Santorini's airport, and connections are available to Mykonos, Crete, and Rhodes several times a week. European charters also fly to Santoríni. Upon arrival, Kapari will arrange a transfer or guests can travel the ten kilometers from the airport to the lodge by taxi or rental car.

Kapari is built into a traditional Santorini village, set on a hilltop and linked by a labyrinth of stairs and alleys. Visitors to the hotel, and to the village of Imerovigli, should be able to climb easily up and down stairs and navigate steep, narrow passageways.

Santorini has a relatively mild climate, with warm, sunny days throughout the summer and rainier days in winter with colder temperatures that rarely dip below 50°F (10°C). From June to September, temperatures range from 75°F to 86°F (24°C to 30°C). Spring and fall are pleasant, with temperatures in the 60s and 70s Fahrenheit.